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Astellas Pharma Sr. Research Associate, Cell Based Therapies in Westborough, Massachusetts

Do you want to be part of an inclusive team that works to develop innovative therapies for patients? Every day, we are driven to develop and deliver innovative and effective new medicines to patients and physicians. If you want to be part of this exciting work, you belong at Astellas!

Astellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. We are committed to turning innovative science into medical solutions that bring value and hope to patients and their families. Keeping our focus on addressing unmet medical needs and conducting our business with ethics and integrity enables us to improve the health of people throughout the world. For more information on Astellas, please visit our website at www.astellas.com .

Astellas Institute of Regenerative Medicine (AIRM) is a wholly-owned subsidiary of Astellas Pharma Inc and focused on the development and commercialization of stem cell and regenerative medicine therapies. Astellas is an R&D-driven global pharmaceutical company whose philosophy is to contribute to the improvement of people's heath around the world through the provision of innovative and reliable pharmaceutical products.

AIRM has a world-class R&D team, and is pursuing a diverse range of disease indications, ranging from macular degeneration (currently in clinical trials) and other ocular indications to vascular and autoimmune disease. AIRM's intellectual property portfolio includes pluripotent stem cell platforms -- both embryonic and induced pluripotent stem cells as well as other cell-based therapy research programs. AIRM is headquartered in Massachusetts.

Astellas is announcing a Sr Research Associate, Cell Based Therapies opportunity at their Astellas Institute of Regenerative Medicine (AIRM) site in Westborough, MA.

Purpose:

We are seeking an enthusiastic and highly motivated Senior Research Associate to join R&D to develop and implement mouse pre-clinical disease models in the vivarium, and support that work with complementary in vitro cell-based assays. This individual will collaborate closely within the team and across functional groups to advance pipeline programs.

Essential Job Responsibilities:

  • Manage in vivo animal studies and strict adherence to IACUC guidelines and internal protocols.

  • Assist with operational management of the vivarium, including interfacing with vivarium management and facilitating efficient resolutions to logistical issues.

  • Performs day-to-day monitoring (animal welfare & in-life study measurements), housing, animal husbandry, and ordering, while collaborating with scientific team and veterinary staff.

  • Mouse ear tagging, dosing via IV, IP, SC, intraocular routes, identify and respond to clinical conditions, proper euthanasia, necropsy and tissue procurement for ex vivo analysis.

  • Independently contributes to scientific experiments, such as tissue post-processing and performing molecular biology or cell-based assays.

  • Proficiency in computer software and animal management software to record and independently analyze scientific data, interpret results, and optimize experimental designs.

  • Communicate results via both oral presentations and written reports

  • Ordering and monitoring of experimental supplies.

  • Detailed note-keeping skills in laboratory notebooks and appropriate databases in timely manner.

  • Ability to troubleshoot and solve technical problems independently.

  • Edit & review IACUC and IBC protocols and amendments.

  • Contribute to the development of novel in vitro assays and in vivo models, including formulating technical SOPs and data capture forms.

Quantitative Dimensions:

  • Ability to perform experiments efficiently and effectively

  • Demonstrate clear conceptual understanding of project goals, experimental design, data analysis and troubleshooting.

  • Excellent communication and interpersonal skills.

Organizational Context:

  • Reports to Sr. Scientist, Research Department

  • Communicates with other members of multidisciplinary teams

Qualifications:

Required:

  • BA/BS in animal science, biology or equivalent with 5+ years relevant laboratory and vivarium-based experience or MS with 2+ years of experience.

  • AALAS Certifications (ALAT, LAT, LATG) preferred; CVT, SRA/SRT a plus

  • Solid prior preclinical animal experience, experience with autoimmune and immune-compromised models.

  • Ensuring EH&S compliance within vivarium settings.

  • Understanding of dosing methodology and guidelines, such as site-specific volume and needle gauge restrictions.

  • Great organizational and documentation skills, keen attention to detail.

  • Ability to work independently as well as collaborate effectively in a team science environment.

  • Proficiency in Excel, Word, PowerPoint and Prism.

  • Adept learner with a willingness to learn new techniques.

  • Excellent oral and written communication skills and interpersonal skills.

Preferred:

  • Strong prior animal handling and understanding of high-caliber animal care.

  • Mammalian cell culture experience, both immortalized cell lines and primary cells.

  • Sound interpersonal (transparency, professionalism, and communication) and collaborative (team oriented, supportive, and interactive) mindset.

  • Current understanding of basic animal models, with knowledge of autoimmune-related disorders desired.

  • Organized and attention to detail for study record documentation according to company SOPs.

Benefits:

  • Medical, Dental and Vision Insurance

  • Generous Paid Time Off options, including Vacation and Sick time, plus national holidays including year-end shut down

  • 401(k) match and annual company contribution

  • Company paid life insurance

  • Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions

  • Long Term Incentive Plan for eligible positions

  • Referral bonus program

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Category Research and Development

Astellas is committed to equality of opportunity in all aspects of employment. EOE including Disability/Protected Veterans

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