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Astellas Pharma Scientist II/Sr. Scientist, Immunology Translational Development in Westborough, Massachusetts

The Astellas Institute of Regenerative Medicine (AIRM) is a wholly-owned subsidiary of Astellas Pharma and focused on the development and commercialization of stem cell and regenerative medicine therapies. Astellas is an R&D-driven global pharmaceutical company whose philosophy is to contribute to the improvement of people's heath around the world through the provision of innovative and reliable pharmaceutical products.

Developing innovative therapies is one of the most challenging, most essential and personally rewarding fields in science. This is the most exciting time to be a part of Astellas, a company with a uniquely collaborative and patient-focused culture. There's something special about working at Astellas. It's reflected in our focus on the people we serve, the way we treat each other and the results we achieve together as a company.

AIRM has a world-class R&D team, and is pursuing a diverse range of disease indications, ranging from macular degeneration (currently in clinical trials) and other ocular indications to vascular and autoimmune disease. AIRM's intellectual property portfolio includes pluripotent stem cell platforms -- both embryonic and induced pluripotent stem cells as well as other cell-based therapy research programs. AIRM is headquartered in Marlborough, Massachusetts.

Astellas is announcing a Scientist II/Sr. Scientist, Immunology Translational Development opportunity at their Astellas Institute of Regenerative Medicine (AIRM) site in Westborough, MA.


We are seeking a Sr. Scientist/Scientist II Translational Science and Development who will advance development of cell therapy products at AIRM including process optimization and characterization of various cell types.

Essential Job Responsibilities:

  • Involved in developing and optimizing procedures required for new product purification, characterization, process optimization
  • Contributes to setting up product specifications in collaboration with relevant groups in Technical Operations
  • Independently designs and implements experiments, analyzes data, draws conclusions, makes suggestions based on results of experiments
  • Independently writes study plans and technical reports
  • Demonstrates expert knowledge of cell biology and immunology principles and technical proficiency in research methods
  • Stays current with scientific literature to proactively identify new objectives and approaches
  • Uses professional concepts and company policies and procedures to solve a wide range of difficult problems in imaginative and practical ways
  • May contribute to writing scientific papers
  • May contribute to preparation of documentation required for regulatory filings
  • May contribute to writing SOPs
  • Maintains accurate records as notebook/batch record/electronic entries in compliance with the Company policy
  • Efficiently collaborates with other groups inside and outside of Technical Operations as needed
  • May participate in the development of patent applications
  • Serves as in-house consultant on scientific and technical issues in transplant immunology
  • Demonstrates technical proficiency, scientific creativity, efficient collaboration with others and independent thought
  • Communicates effectively with manager, group members and other team members
  • Carries out work in compliance with Astellas Health and Safety policies
  • Ensures data are of high quality and the projects are on time and within budget
  • May manage one or more employees and takes part in their annual goal writing and performance appraisal ensuring that employee development objectives are met
  • May be a Project Leader for internal or cross-functional projects
  • May provide guidance and oversee the activities of other lower-level personnel
  • Creates a positive work environment promoting teamwork, mutual respect, encouraging change, innovation, and accountability at all levels
  • Effectively contributes to complex work group or long-term project with the objectives of a department, function and overall company
  • Adapts to new projects and challenges with a constructive attitude
  • May be involved in technology transfer and training of others
  • May be involved in external collaborations



  • Education Requirements:

  • Scientist II: Ph.D with 3 + years of experience, MS with 7+ years of experience or a BS with 10+ years of experience

  • Scientist: Ph.D with 5 + years of experience, MS with 8+ years of experience or a BS with 12+ years of experience
  • Solid knowledge of cell biology and immunology principles
  • Solid working knowledge of research methods in cell and molecular biology including proficiency in cell culture
  • Solid working knowledge of research methods in immunology, including in vitro and in vivo settings and multi-color flow cytometry
  • Working knowledge of routine and semi-routine laboratory procedures (QPCR, FACS, immunodetection, microscopy)
  • Knowledge of applicable laboratory equipment including automation
  • Stays current with scientific literature in the field, performs literature searches and creatively uses it for planning research strategies
  • Demonstrated ability to independently design research strategy and effectively implement experiments in a timely manner
  • Ability to analyze data, draw conclusions, make scientific recommendations and troubleshoot
  • Proficiency in writing technical and scientific reports based on data analysis, ability to contribute to writing scientific manuscripts and prepare presentations
  • Ability to work flexible hours and weekends/holidays
  • Efficiency at managing multiple projects while working under tight timelines
  • Flexibility and willingness to tackle new challenges outside of their comfort zone
  • Result-oriented, self-starter, team player


  • Experience in one or more of the following areas: pluripotent stem cells and their differentiation; retinal, mesenchymal stem, or vascular cells; ophthalmology, transplantation
  • Working knowledge of high throughput technologies such as single cell sequencing or Nanostring
  • Familiarity with GLP/GMP environment and ability to work under SOPs
  • Experience with assay development and SOP writing
  • Experience with technology transfer and training others


Equal Opportunity Employer Minorities/Women/Protected Veterans/Disabled Category Research and Development