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Astellas Pharma Scientist I, Stem Cell Research in Westborough, Massachusetts

The Astellas Institute of Regenerative Medicine (AIRM) is a wholly-owned subsidiary of Astellas Pharma and focused on the development and commercialization of stem cell and regenerative medicine therapies. Astellas is an R&D-driven global pharmaceutical company whose philosophy is to contribute to the improvement of people's heath around the world through the provision of innovative and reliable pharmaceutical products.

Developing innovative therapies is one of the most challenging, most essential and personally rewarding fields in science. This is the most exciting time to be a part of Astellas, a company with a uniquely collaborative and patient-focused culture. There's something special about working at Astellas. It's reflected in our focus on the people we serve, the way we treat each other and the results we achieve together as a company.

AIRM has a world-class R&D team, and is pursuing a diverse range of disease indications, ranging from macular degeneration (currently in clinical trials) and other ocular indications to vascular and autoimmune disease. AIRM's intellectual property portfolio includes pluripotent stem cell platforms -- both embryonic and induced pluripotent stem cells as well as other cell-based therapy research programs. AIRM is headquartered in Marlborough, Massachusetts.

Astellas is announcing a Scientist I, Stem Cell Research opportunity at their Astellas Institute of Regenerative Medicine (AIRM) site in Westborough, MA.

Purpose:

The Scientist conducts novel cell biology and molecular laboratory research. Coordinates research efforts and makes key technical contribution affecting the direction of the group and/or project. Performs experiments and analytical procedures, applying a wide variety of scientific principles and concepts. Applies expertise and breadth of knowledge to ongoing research and development of new project proposals.

Essential Job Responsibilities:

  • Performs laboratory-based research independently and/or in collaboration with others.

  • Makes detailed observations, analyzes data and interpret results.

  • Maintain multiple PSC lines and perform differentiation into vascular cell lineages.

  • Performs viral transduction/engineering of pluripotent stem cell lines and/or their derivatives.

  • Perform in vitro assays, data collection, analysis, and interpret results to characterize vascular progenitor populations and derivatives thereof.

  • Prepares technical reports, summaries, protocols, and quantitative analyses. Investigates, creates and develops new methods and technologies for project advancement.

  • Maintains high level of professional expertise through familiarity with scientific literature and novel technologies and help manage external collaborations.

  • Develop and adhere to SOPs and workflows with proper documentation.

Qualifications:

Required

  • Ph.D. with 0-3 years, BS with MS with 6+ years or BS with 8+ years of laboratory experience.

  • Experience with human pluripotent stem cell culture (ESC or iPSC) and differentiation.

  • Working knowledge of nucleic acid/protein isolation, RT-PCR, western blot, flow cytometry, ELISA and cell imaging.

  • Excellent written, verbal communication and interpersonal skills and ability to work independently and collaborate within a team-based environment.

  • Ability to work flexible schedule including weekends.

Preferred

  • Ph.D. with 0-3 years, or exceptional MS with 6+ years of laboratory experience in stem cell biology, cell and tissue engineering, developmental biology or related biological life sciences.

  • Solid background in lentiviral production and transgene expression.

  • Experience in vascular disease models and pathophysiology.

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Category Research and Development

Astellas is committed to equality of opportunity in all aspects of employment. EOE including Disability/Protected Veterans

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