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Astellas Pharma Scientist I PSC and Liver Research in Westborough, Massachusetts

Scientist I, PSC and Liver Research

Do you want to be part of an inclusive team that works to develop innovative therapies for patients? Every day, we are driven to develop and deliver innovative and effective new medicines to patients and physicians. If you want to be part of this exciting work, you belong at Astellas!

Astellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. We are committed to turning innovative science into medical solutions that bring value and hope to patients and their families. Keeping our focus on addressing unmet medical needs and conducting our business with ethics and integrity enables us to improve the health of people throughout the world. For more information on Astellas, please visit our website at .

Astellas Institute of Regenerative Medicine (AIRM) is a wholly-owned subsidiary of Astellas Pharma Inc and focused on the development and commercialization of stem cell and regenerative medicine therapies. Astellas is an R&D-driven global pharmaceutical company whose philosophy is to contribute to the improvement of people's heath around the world through the provision of innovative and reliable pharmaceutical products.

AIRM has a world-class R&D team, and is pursuing a diverse range of disease indications, ranging from macular degeneration (currently in clinical trials) and other ocular indications to vascular and autoimmune disease. AIRM's intellectual property portfolio includes pluripotent stem cell platforms -- both embryonic and induced pluripotent stem cells as well as other cell-based therapy research programs. AIRM is headquartered in Massachusetts.

Astellas is announcing a Scientist I, PSC and Liver Research opportunity at their Astellas Institute of Regenerative Medicine (AIRM) site in Westborough, MA.


Conducts novel cell biology and molecular laboratory research. Performs cutting-edge experiments and analytical procedures, applying a wide variety of scientific principles and concepts. Coordinates research efforts and makes key technical contribution affecting the direction of the group and/or project.

Essential Job Responsibilities:

  • Performs laboratory-based research independently and/or in collaboration with others.

  • Maintains and scales-up functional iPSC-derived liver cells for in vivo studies.

  • Makes detailed observations, analyzes data and interprets results.

  • Performs viral transduction/engineering of pluripotent stem cell lines and/or their derivatives.

  • Performs in vitro assays, data collection, analysis, and interprets results to characterize liver progenitor populations and derivatives thereof.

  • Prepares technical reports, summaries, protocols, and quantitative analyses. Investigates, creates and develops new methods and technologies for project advancement.

  • Maintains high level of professional expertise through familiarity with scientific literature and novel technologies.

  • Develops and adheres to SOPs and workflows with proper documentation.

Quantitative Dimensions:

  • Consistently completes work on time/in accordance with deadlines and does so with minimal supervision.

  • Communicates effectively with line manager and group members, building trust and engagement in the team ensuring timely completion of activities and projects.

  • Consistently achieves individual goals in alignment with overall business objectives.

Organizational Context:

  • Reports to Senior Scientist



  • PhD with 0-3 years', MS with 6+ years', or BS with 8+ years' of laboratory experience in stem cell biology, cell and tissue engineering, developmental biology or related biological life sciences.

  • Excellent working experience with aseptic mammalian cell culture skills.

  • Working knowledge of various in vitro assays for liver cell characterization.

  • Working knowledge of nucleic acid/protein isolation, RT-PCR, western blot, flow cytometry, ELISA and cell imaging.

  • Excellent written, verbal communication and interpersonal skills and ability to work independently and collaborate within a team-based environment.

  • Communicate results to team members and collaborators.

  • Ability to work flexible schedule including weekends.


  • Experience with human pluripotent stem cell culture (ESC or iPSC) and differentiation into endoderm and hepatocyte lineages.

  • Working knowledge of preclinical animal models of liver diseases.


  • Medical, Dental and Vision Insurance

  • Generous Paid Time Off options, including Vacation and Sick time, plus national holidays including year-end shut down

  • 401(k) match and annual company contribution

  • Company paid life insurance

  • Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions

  • Long Term Incentive Plan for eligible positions

  • Referral bonus program


Category Research and Development

Astellas is committed to equality of opportunity in all aspects of employment. EOE including Disability/Protected Veterans