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Astellas Pharma Senior Research Associate, Bioanalytics in South San Francisco, California

About Astellas Gene Therapies

Astellas Gene Therapies is an Astellas Center of Excellence developing genetic medicines for patients with rare, life-threatening diseases. Based on our innovative approach to developing genetic medicines, as well as our industry-leading internal manufacturing capability and expertise, we have become the Astellas Center of Excellence for their newly-created Genetic Regulation Focus Area. We are currently exploring three gene therapy modalities: gene replacement, exon skipping gene therapy, and vectorized RNA knockdown, with plans to expand our focus and geographic reach under Astellas. We are based in San Francisco, with manufacturing and laboratory facilities in South San Francisco and Sanford, North Carolina. For more information, please visit our website: www.audentestx.com

About Astellas

Astellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. We are promoting the Focus Area Approach that is designed to identify opportunities for the continuous creation of new drugs to address diseases with high unmet medical needs by focusing on Biology and Modality. Furthermore, we are also looking beyond our foundational Rx focus to create Rx+® healthcare solutions that combine our expertise and knowledge with cutting-edge technology in different fields of external partners. Through these efforts, Astellas stands on the forefront of healthcare change to turn innovative science into value for patients. For more information, please visit our website at https://www.astellas.com/en.

Our Values:

  • Be BOLD (Find a Way)

  • Care Deeply -- for our patients, each other and our work

  • #GSD (Get Stuff Done)

What is the catalyst for you in your professional career? Are you ready to be a part of a bold, innovative company, to make a change and to make a difference? Listed below is a current opening for a smart, driven, experienced, and just plain nice individual who wants to join us and be a part of our journey.

The Role

The Senior Research Associate will play a critical role in the development, optimization, and qualification of a variety of bioanalytical methods. These methods include ELISA, ECL, Western Blot, PCR, enzymological, and cell based measurements. The Associate will also employ the methods for routine analysis of study samples. As a key member of the Bioanalytics team, you will be contributing directly to these activities as hands-on experimenter and by analysis and interpretation of the data. The position will be located in our laboratory facilities in South San Francisco, CA.

Primary Responsibilities

  • Routine extraction and preparation of protein and nucleic acid samples from a variety of biological specimens, including tissues.

  • Development and optimization of ELISA, MSD, Western Blot, and cell based methods

  • Development and optimization of enzymatic assays; routine analysis of biological samples with such assays

  • Quantification of proteins and antibodies in biological samples using ELISA and MSD

  • Purification of monoclonal and polyclonal antibodies

  • Labelling of critical reagents such as proteins and antibodies with a variety of tags

  • Qualification and inventory reagents

  • Quantification DNA and RNA in biological samples using qPCR, ddPCR and RT-PCR

  • Tabulation of data in prescribed format amenable to analysis by statistical applications

  • Analysis of experimental results

  • Contemporaneous and error-free documentation of assay execution and results in lab notebooks and organized electronic folders

  • Consultation of scientific literature and other scientists to better understand scientific experiments and problems, and come up with solutions to emerging problems

About you

Must Have/Required

  • Bachelor's degree in Biochemistry, Molecular Biology, Life Sciences or a related discipline with 8+ years' experience or a Master's degree with 5+ years' experience

  • Hands on experience on Ligand Binding Assay (e.g., ELISA, MSD) method development and execution in biological sample analysis

  • Hands on experience with molecular assays such as QPCR, ddPCR

  • Thorough understanding and proven experience with biochemical techniques, such as isolation and quantification of proteins, ELISA, Western Blot, enzymological, and cell based methods

  • Strong communication and interpersonal skills

  • Prior success working flexibly in a cross-functional team environment

  • Models our Core Values: Be Bold, Care Deeply, #GetStuffDone -- is experienced as someone who exemplifies the culture we want to create; operates with transparency; is trusted

May Have/Preferred

  • Experience with SoftMax Pro, GraphPad, Excel (Pivot Table), and similar applications

  • Experience with molecular biology techniques, such as isolation and quantification of nucleic acids, cDNA synthesis, cloning, DNA sequencing, RT-qPCR, etc.

  • Familiarity with FDA bioanalytical method validation guideline

All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, sexual orientation, gender identity, national origin, protected veteran status, or on the basis of disability.

#LI-KW1

Category Research and Development

Astellas is committed to equality of opportunity in all aspects of employment. EOE including Disability/Protected Veterans

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