Scientist I, Tumor Immuno-Biology, Immunohistochemistry Lead

Astellas Pharma is a pharmaceutical company conducting business in more than 70 countries around the world. We are committed to turning innovative science into medical solutions that bring value and hope to patients and their families. Keeping our focus on addressing unmet medical needs and conducting our business with ethics and integrity enables us to improve the health of people throughout the world. For more information on Astellas, please visit our website at .

Xyphos Biosciences, an affiliate of Astellas Pharma, is developing a novel adoptive cell therapy technology platform and building a pipeline of innovative products for oncology. We are a rapidly growing team of research and scientific professionals, passionate about turning science and innovation into medical solutions through our cell therapy technology platform.

Astellas is announcing a Scientist I, Tumor Immuno-Biology, Immunohistochemistry Lead opportunity at their Xyphos site in South San Francisco, CA.

Job Description:

Xyphos Biosciences (South San Francisco, CA), an Astellas company is seeking Scientist I to join our Tumor Immuno-Biology group. The scientific focus of this role is improving the permissiveness of solid tumors to immune effector cells. The prospective hire is expected to advance understanding of solid tumor microenvironment. The successful candidate will focus on addressing the questions of T- and NK cells homing to tumor site, challenges of immunosuppressive components in the TME, tumor heterogeneity and physical barrier. The position requires experience in solid tumor biology, cell biology and/or immunology. The successful candidate is expected to establish and support in-house pathology and immunohistochemistry efforts aiming in enhance our understanding of cell therapy in solid tumors.

Essential Job Responsibilities:

  • Establish and oversee day to day operation of Astellas Immuno-histochemisty Core, South San Francisco

  • Execute sample preparation for the colorimetric and fluorescent analyses of antigen expression in tissue samples

  • Design and execute studies focused on understanding immune cells in the tumor microenvironment by advanced multi-dimensional immunofluorescence imaging

  • Develop IHC/IF protocols for novel targets

  • Utilize Advance Image processing software for sample analysis

  • Contribute to the development of Astellas data share platform in collaboration with Astellas AI department

  • In close collaboration with in vivo Pharmacology team perform ex vivo tissue processing and analysis

  • Effectively communicate with team members to efficiently conduct studies, articulate experimental details and results with other members of the Astellas research organization



  • PhD in biophysics or a closely related fields with 2+ years postdoctoral experience in an academic or industry setting.

  • Hands on experience with tissue processing, sectioning, colorimetric and fluorescent analysis

  • Hands on experience with flow cytometry with ability to design and implement multi-color flow assays

  • Familiarity with methods used to validate tumor and immune cells

  • Excellent verbal, written, and interpersonal communication skills are essential with collegiality being a defining attribute

  • Strong work ethic with a dedicated mindset of proactively identifying and productively filling gaps

  • Ability to maintain highly detailed, accurate, and timely records of experimental designs, results, and data analysis

Salary Range

  • $99K – $132K (NOTE: Final salary could be more or less, based on experience)


  • Medical, Dental and Vision Insurance

  • Generous Paid Time Off options, including Vacation, Sick time, plus national holidays including Heritage Days, and Summer and Winter Breaks

  • 401(k) match and annual company contribution

  • Company paid life insurance

  • Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions

  • Long Term Incentive Plan for eligible positions

  • Referral bonus program

Category Xyphos Biosciences

Astellas is committed to equality of opportunity in all aspects of employment.

EOE including Disability/Protected Veterans