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Astellas Pharma Research Associate I/II, Vector Biosciences in South San Francisco, California

About Astellas Gene Therapies

Astellas Gene Therapies is a leading AAV-based genetic medicines company focused on developing and commercializing innovative products for serious rare neuromuscular diseases. We are leveraging our AAV gene therapy technology platform and proprietary manufacturing expertise to develop programs across three modalities: gene replacement, vectorized exon skipping, and vectorized RNA knockdown. Our product candidates are showing promising therapeutic profiles in clinical and preclinical studies across a range of neuromuscular diseases. Astellas Gene Therapies is a focused, experienced and passionate team driven to improve the lives of patients.

Astellas Gene Therapies leverages strong, global relationships with the patient, research, and medical communities, and we take pride in carefully selecting our colleagues. Listed below is a current opening for a smart, driven, experienced, and just plain nice individual who wants to join us on our journey.

The Role

The Research Associate will support the Vector Biosciences team and assist with the development of novel AAV gene therapy vectors using molecular biology techniques. The Research Associate will be located in our South San Francisco R&D laboratories.

Responsibilities

  • Execute cloning projects to create novel AAV candidate vectors using a variety of techniques (i.e: Gibson assembly, restriction digest, ligation, etc.).

  • Analyze clones by PCR, Sanger Sequencing and agarose gel electrophoresis.

  • Collect and evaluate data; prepare reports, summaries and presentations; maintain and update laboratory notebook and the laboratory information management system, as appropriate, according to company policy

  • Collaborate with scientists to design and execute scientific experiments using relevant molecular biology technologies.

  • Perform as part of a multi-disciplinary team and troubleshoot problems/identify solutions to technical challenges.

  • Additional duties as assigned

Required Qualifications

  • Bachelor's degree in Molecular Biology, Biology, Life Sciences or a related discipline with 2+ years of experience or a Master's Degree with 1+ years of experience in molecular biology techniques.

  • Strong molecular biology skill set, set including but not limited to isolation and quantification of DNA, PCR, qPCR, ddPCR, etc. , genomic analysis, primer design and sequencing and various cloning techniques

  • Experience with DNA sequence analysis software

  • Models our Core Values: Be Bold: Find a Way, Care Deeply, Get Stuff Done -- is experienced as someone who exemplifies the culture we want to create; operates with transparency; is trusted

  • Preferred Qualifications

  • Experience with AAV and other viral constructs cloning is preferred.

  • Industry experience

Benefits:

  • Medical, Dental and Vision Insurance

  • Generous Paid Time Off options, including Vacation and Sick time, plus national holidays including year-end shut down

  • 401(k) match and annual company contribution

  • Company paid life insurance

  • Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions

  • Long Term Incentive Plan for eligible positions

  • Referral bonus program

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Category Research and Development

Astellas is committed to equality of opportunity in all aspects of employment.

EOE including Disability/Protected Veterans

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