About Astellas Gene Therapies

Astellas Gene Therapies is an Astellas Center of Excellence developing genetic medicines for patients with rare, life-threatening diseases. Based on our innovative approach to developing genetic medicines, as well as our industry-leading internal manufacturing capability and expertise, we have become the Astellas Center of Excellence for their newly-created Genetic Regulation Focus Area. We are currently exploring three gene therapy modalities: gene replacement, exon skipping gene therapy, and vectorized RNA knockdown, with plans to expand our focus and geographic reach under Astellas. We are based in San Francisco, with manufacturing and laboratory facilities in South San Francisco and Sanford, North Carolina.

About Astellas

Astellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. We are promoting the Focus Area Approach that is designed to identify opportunities for the continuous creation of new drugs to address diseases with high unmet medical needs by focusing on Biology and Modality. Furthermore, we are also looking beyond our foundational Rx focus to create Rx+® healthcare solutions that combine our expertise and knowledge with cutting-edge technology in different fields of external partners. Through these efforts, Astellas stands on the forefront of healthcare change to turn innovative science into value for patients. For more information, please visit our website at https://www.astellas.com/en.

Our Values:

  • Be BOLD (Find a Way)

  • Care Deeply – for our patients, each other and our work

  • #GSD (Get Stuff Done)

What is the catalyst for you in your professional career? Are you ready to be a part of a bold, innovative company, to make a change and to make a difference? Listed below is a current opening for a smart, driven, experienced, and just plain nice individual who wants to join us and be a part of our journey.

The Role

The Research Associate II will support activities within the Discovery Biology Department. This position involves application of several techniques to produce, purify and characterize AAV viral vectors. The Research Associate will be located in our South San Francisco R&D laboratories.

Responsibilities

  • Purification and characterization of AAV vectors using column chromatography.

  • Analysis of purified AAV vectors by SDS-PAGE, agarose gel electrophoresis, ddPCR, RT-PCR and UV.

  • Support AAV production by maintaining, banking, and transfecting mammalian cells in culture.

  • Conduct and troubleshoot experiments, independently and in collaboration with colleagues, to produce novel AAV vectors.

  • Collect and evaluate data; prepare reports, summaries and presentations; maintain and update laboratory notebook and the laboratory information management system, as appropriate, according to company policy.

Required Qualifications

  • Bachelor’s degree in Molecular Biology, Cell Biology, Life Sciences or a related discipline with 2-5 years of experience or a Master’s Degree with 1+ years of experience in protein purification techniques.

  • Demonstrated experience with AKTA chromatography in purifying proteins/antibodies. Experience with AAV purification using AKTA chromatography is highly desired.

  • Models our Core Values: Be Bold, Care Deeply, #GetStuffDone - is experienced as someone who exemplifies the culture we want to create; operates with transparency.

Preferred Qualifications

  • Experience with AKTA FPLC for AAV purification.

Salary Range : $72,800 -$ 97,000- (NOTE: Final salary could be more or less, based on experience)

Benefits:

  • Medical, Dental and Vision Insurance

  • Generous Paid Time Off options, including Vacation, Sick time, plus national holidays including Heritage Days, and Summer and Winter Breaks

  • 401(k) match and annual company contribution

  • Company paid life insurance

  • Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions

  • Long Term Incentive Plan for eligible positions

  • Referral bonus program

All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, sexual orientation, gender identity, national origin, protected veteran status, or on the basis of disability.

#LI-TR1

Category Gene Therapy Research & Technical Operations

Astellas is committed to equality of opportunity in all aspects of employment.

EOE including Disability/Protected Veterans

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