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Astellas Pharma Research Associate II, in vivo in South San Francisco, California

Developing innovative therapies is one of the most challenging and rewarding fields in science. This is the most exciting time to be a part of Astellas, a company with a uniquely collaborative and patient-focused culture.

There's something special about working at Astellas. It's reflected in our focus on the people we serve, the way we treat each other and the results we achieve together as a company.

Xyphos Biosciences , an affiliate of Astellas Pharma Inc. is developing a novel adoptive cell therapy technology platform and building a pipeline of innovative products.

We are a rapidly growing team of research and scientific professionals, passionate about turning science and innovation into medical solutions through our cell therapy technology platform. Through our diversity, scientific knowledge, professional rigor and focus on innovation, we are merging our technology with the Astellas drug development expertise to unlock cures to many therapies. Join our team of committed, enthusiastic professionals devoted to making the most effective, life-saving cell therapy products in the world.

Astellas is announcing a Research Associate II, in vivo opportunity at their Xyphos site in South San Francisco, CA.


The primary purpose of the Research Associate II is to support in vivo pharmacology activities by performing cell culture and immunological assays, analyzing data, and drafting reports. This individual will work primarily in a laboratory setting to advance CAR adoptive cell therapy programs for treatment of cancer

Essential Job Responsibilities:

  • Utilizes established techniques in cell culture, cell biology and immunology to generate and analyze data in an accurate and reproducible manner.

  • Routinely feeds, passages, expands and freezes multiple adherent and suspension cell lines for in vivo studies

  • Collects and processes rodent blood samples and performs various in vitro and ex-vivo cytokine and immune cell assays

  • Performs immunophenotyping of cell subsets using flow cytometry

  • Maintains accurate record keeping in laboratory notebooks and appropriate databases in a timely manner.

  • Writes technical reports detailing procedures, outcomes, and observations.



  • BS with 3+ years; MS with 0-2 years relevant laboratory experience.

  • Experienced in aseptic tissue culture and multi-color flow cytometry techniques

  • Willingness and ability to learn new skills

  • Ability to analyze data and write concise reports

  • Will require attention to detail and a dedicated work ethic


  • Small animal handling experience

  • Industry work or internship experience, especially in CAR-T cell or immuno-oncology field

  • Proficiency in data analysis software (e.g. FlowJo, GraphPad)

  • Familiarity with one or more of the following techniques: ELISA/ELISPOT/Luminex/CBA/MSD

  • Familiarity with PBMC isolation from blood products, cell separation techniques


  • Medical, Dental and Vision Insurance

  • Generous Paid Time Off options, including Vacation and Sick time, plus national holidays including year-end shut down

  • 401(k) match and annual company contribution

  • Company paid life insurance

  • Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions

  • Long Term Incentive Plan for eligible positions

  • Referral bonus program


Category Research and Development

Astellas is committed to equality of opportunity in all aspects of employment. EOE including Disability/Protected Veterans