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Astellas Pharma Research Associate II, CAR T-Cells in South San Francisco, California

21-POS00047159 - Research Associate II, CAR T-Cells

Do you want to be part of an inclusive team that works to develop innovative therapies for patients? Every day, we are driven to develop and deliver innovative and effective new medicines to patients and physicians. If you want to be part of this exciting work, you belong at Astellas!

Astellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. We are committed to turning innovative science into medical solutions that bring value and hope to patients and their families. Keeping our focus on addressing unmet medical needs and conducting our business with ethics and integrity enables us to improve the health of people throughout the world. For more information on Astellas, please visit our website at .

Xyphos Biosciences , an affiliate of Astellas Pharma Inc. is developing a novel adoptive cell therapy technology platform and building a pipeline of innovative products.

We are a rapidly growing team of research and scientific professionals, passionate about turning science and innovation into medical solutions through our cell therapy technology platform. Through our diversity, scientific knowledge, professional rigor and focus on innovation, we are merging our technology with the Astellas drug development expertise to unlock cures to many therapies. Join our team of committed, enthusiastic professionals devoted to making the most effective, life-saving cell therapy products in the world.

Astellas is announcing a Research Associate II, CAR T-Cells opportunity at their Xyphos site in South San Francisco, CA.


The primary purpose of the Research Associate II is to support discovery efforts for novel chimeric antigen receptor adoptive cell therapies for treatment of cancer. This position will work primarily in a laboratory setting with Scientist and R&D teams.

Essential Job Responsibilities:

  • Performs immuno-oncology assays (e.g. cytotoxicity, cytokine production) for functional characterization of CAR T and CAR NK cells

  • Characterizes antibodies by flow cytometry for lead discovery and lead optimization

  • Adheres to established standard protocols for reliable and consistent data generation

  • Works independently and with careful attention to detail, records procedure/data/results accurately and in a timely manner, interprets data, draws conclusions, and presents in meetings

  • Collaborates with other members of the R&D team and with other teams within Astellas

  • Involved with R&D laboratory operation. Performs other duties or special projects as assigned



  • BS degree with 3+ years or MS with 0-2 years of laboratory experience in immunology, cancer biology, molecular biology, or similar field

  • 1+ years of relevant hands-on laboratory experience (internship, work, or academic research)

  • Proficiency at multi-color flow cytometry (4+ channels), including operating flow cytometers, analyzing flow data

  • Experience in mammalian cell culture, specifically in immune cell functional assays with readouts for at least one: cytotoxicity, activation, proliferation, cytokine secretion

  • Good math skills and attention to detail in experimentation and record keeping

  • Eagerness to learn about cutting-edge science in cancer biology, immunology, and CAR-T cells

  • Willingness to be independent in the lab, excellent work ethic, team-player attitude, crisp communication skills, ability to work weekends as needed


  • Industry work or internship experience, especially in CAR-T cell or immuno-oncology field

  • Proficiency in data analysis software (e.g. FlowJo, GraphPad)

  • Familiarity with one or more of the following techniques: ELISA/ELISPOT/Luminex/CBA/MSD

  • Familiarity with PBMC isolation from blood products, cell separation techniques


  • Medical, Dental and Vision Insurance

  • Generous Paid Time Off options, including Vacation and Sick time, plus national holidays including year-end shut down

  • 401(k) match and annual company contribution

  • Company paid life insurance

  • Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions

  • Long Term Incentive Plan for eligible positions

  • Referral bonus program


Category Research and Development

Astellas is committed to equality of opportunity in all aspects of employment. EOE including Disability/Protected Veterans