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Astellas Pharma Principal Research Associate II, in vivo in South San Francisco, California

Developing innovative therapies is one of the most challenging and rewarding fields in science. This is the most exciting time to be a part of Astellas, a company with a uniquely collaborative and patient-focused culture.

There's something special about working at Astellas. It's reflected in our focus on the people we serve, the way we treat each other and the results we achieve together as a company.

Xyphos Biosciences , an affiliate of Astellas Pharma Inc. is developing a novel adoptive cell therapy technology platform and building a pipeline of innovative products.

We are a rapidly growing team of research and scientific professionals, passionate about turning science and innovation into medical solutions through our cell therapy technology platform. Through our diversity, scientific knowledge, professional rigor and focus on innovation, we are merging our technology with the Astellas drug development expertise to unlock cures to many therapies. Join our team of committed, enthusiastic professionals devoted to making the most effective, life-saving cell therapy products in the world.

Astellas is announcing a Prinicipal Research Associate II, in vivo opportunity at their Xyphos site in South San Francisco, CA.


The primary purpose of the Principal Research Associate is to support in vivo pharmacology activities byperforming small animal research studies, analyzing data, and drafting reports. This individual will work primarily in a laboratory setting to advance CAR adoptive cell therapy programs for treatment of cancer.

Essential Job Responsibilities:

  • Utilizes broad scientific expertise in the area of animal pharmacology to initiate and effectively

  • execute in vivo animal studies.

  • Performs IV, IP and SQ injections along with scheduled monitoring of tumor growth and animals'

  • health including weight.

  • Establish and maintain new animal cancer models.

  • Collects and processes rodent blood and tissue samples

  • Routinely feeds, passages, expands and freezes multiple adherent and suspension cell lines for in

  • vivo studies

  • Maintains accurate record keeping in laboratory notebooks and appropriate databases in a timely manner

  • Writes technical reports detailing procedures, outcomes, and observations.



  • BS with 8+ years; MS with 4+ years relevant laboratory experience.

  • Demonstrated ability to perform dosing (IV, IP, and SQ injections), blood draw, monitoring/scoring,

  • necropsy and specimen collection

  • Demonstrated knowledge of lab animal science guidelines / laws and welfare laws.

  • Experienced in aseptic tissue culture

  • Willingness and ability to learn new skills

  • Ability to analyze data and write concise reports

  • Will require attention to detail and a dedicated work ethic


  • Familiarity with one or more of the following techniques: IVIS in vivo imaging system, Multi-color

  • flow cytometry techniques or ELISA would be a plus.

  • Industry work or internship experience, especially in CAR-T cell or immuno-oncology field

  • Benefits:

  • Medical, Dental and Vision Insurance

  • Generous Paid Time Off options, including Vacation and Sick time, plus national holidays including year-end shut down

  • 401(k) match and annual company contribution

  • Company paid life insurance

  • Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions

  • Long Term Incentive Plan for eligible positions

  • Referral bonus program


Category Research and Development

Astellas is committed to equality of opportunity in all aspects of employment. EOE including Disability/Protected Veterans