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Astellas Pharma Senior Scientist, Antigen Presentation in Seattle, Washington

Universal Cells is focused on the development and commercialization of stem cell and regenerative medicine therapies. We conduct clinical-grade gene editing of stem cells and have a major effort in R&D. We design and produce stem cells that avoid rejection, and we engineer cells with improved therapeutic properties, all through our world-class gene editing platform.

Our goal is to provide cells for regenerative medicine applications that can treat all patients. Through internal R&D, and our corporate partnerships, we are pursuing a diverse range of disease indications, including blindness, cancer, vascular insufficiency, and autoimmune diseases.

Universal Cells is announcing a Senior Scientist, Antigen Presentation opportunity at their facility in Seattle, WA.

Purpose:

We are seeking an innovative and motivated R&D Senior Scientist for Antigen Presentation, to develop stem cell-derived, engineered, antigen presenting cells to control T cell immune responses. Methods will be established for antigen presentation that will inform preclinical studies for autoimmune, allergy, and vaccination applications.

Universal Cells is now part of Astellas!

Universal Cells is a wholly-owned subsidiary of Astellas Pharma. Astellas is an R&D-driven global pharmaceutical company whose philosophy is to contribute to the improvement of people's health around the world through the provision of innovative and reliable pharmaceutical products.

Essential Job Responsibilities:

  • Will contribute to the design and engineering strategy to achieve clonal antigen presentation of defined HLA class II molecules presenting specific antigens to T cells.
  • Will edit pluripotent stem cells.
  • Will differentiate gene-edited pluripotent stem cells into functional antigen presenting cells.
  • Will assess the impact of engineered antigen presentation on T cells using in vitro assays and animal models.
  • Will perform additional editing to modulate T cell responses for therapeutic benefit.
  • Will serve as a subject matter expert on experiment methods and techniques for antigen presentation and T cell biology.
  • Will maintain familiarity with scientific literature and apply knowledge appropriately to research project.
  • Will collaborate with colleagues within Universal Cells, at other Astellas locations, and with corporate partners.

Qualifications:

Required

  • PhD degree and 5+ years of relevant post-graduate experience in immunology.
  • MS with 8+ or BS with 12+ of highly relevant experience
  • Experience with antigen-presentation and T cell assays.
  • Wide experience with in vitro immune cell assays.

Preferred

  • Experience with CD4+ T cell biology.
  • Experience with regulatory T cells.
  • Experience with stem cells and their differentiation
  • Experience with gene-editing and cell engineering.
  • Experience with animal models.

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Equal Opportunity Employer Minorities/Women/Protected Veterans/Disabled

Category Research and Development

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