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Astellas Pharma Scientist I, TME Gene Editing in Seattle, Washington

Scientist I, TME Gene Editing

Do you want to be part of an inclusive team that works to develop innovative therapies for patients? Every day, we are driven to develop and deliver innovative and effective new medicines to patients and physicians. If you want to be part of this exciting work, you belong at Astellas!

Astellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. We are committed to turning innovative science into medical solutions that bring value and hope to patients and their families. Keeping our focus on addressing unmet medical needs and conducting our business with ethics and integrity enables us to improve the health of people throughout the world. For more information on Astellas, please visit our website at www.astellas.com.

Universal Cells , an affiliate of Astellas located in Seattle, WA, is focused on the development and commercialization of stem cell and regenerative medicine therapies. We conduct clinical-grade gene editing of stem cells to produce cells that avoid rejection and can be used in allogeneic cell therapy treatments to treat all patients that need them.

OUR GOAL - ONE CELL FOR EVERYONE

NO IMMUNE SUPPRESSION. NO DONOR MATCHING. NO REJECTION.

We are a dynamic team of research and scientific professionals who are passionate about turning science and innovation into medical solutions. Through our diversity, scientific knowledge, professional rigor and focus on innovation, we are merging our technology with the Astellas drug development expertise to unlock cures to many therapies. Join our team of committed, enthusiastic professionals devoted to making the most effective, life-saving cell therapy products in the world.

Universal Cells (UCI) is announcing a Scientist I, TME Gene Editing opportunity at their facility in Seattle, WA .

Purpose:

The primary purpose of the Scientist I position is to provide scientific expertise towards gene editing in hematopoietic cells. This position will oversee editing experiments to confer novel, targeted immune functions to our Universal Donor Cell.

Essential Job Responsibilities:

  • Develop and execute strategies for gene-editing in pluripotent stem cells and stem cell-derived hematopoietic cells.

  • Utilize molecular biology techniques to generate editing constructs.

  • Perform characterization of edited cells, including phenotyping.

  • Prepare technical reports, summaries, protocols, and presentations. Regularly present findings at group meetings.

  • Apply scientific rigor to all aspects of the job, including experimental design, analysis, and interpretation.

  • Collaborate with colleagues across Universal Cells and other Astellas sites.

  • Perform other duties as assigned or special projects as needed.

Quantitative Dimensions:

  • The Scientist I position is integral to achieving our scientific strategy for pre-clinical studies of our edited Universal Donor Cell in collaboration with other Astellas sites.

  • Potential to generate IP.

Organizational Context:

  • Reports to Senior Scientist.

  • Closely collaborates with colleagues within Research & Development at Universal Cells and other Astellas sites.

Qualifications:

Required:

  • D. in Biology, Immunology, or a related field, with an additional 0-3+ years of relevant post-graduate experience, MS degree with 6+ years of relevant experience, or BS with 8+ years of relevant experience.

  • In-depth knowledge and experience with gene editing, as demonstrated by strong publication or patent record.

  • Experience with hematopoietic cell isolation, culture, or differentiation.

  • Experience with multi-color flow cytometry.

  • Strong molecular biology skills (e.g. PCR, cloning, etc.).

  • Demonstrated ability to move a project forward and work in team settings.

  • Strong organizational, time management, and problem-solving skills with scientific attention to detail.

  • Ability to work independently and effectively collaborate with other teams.

  • Excellent communication and interpersonal skills.

  • Strong work ethic with a passion for working in a fast-paced, dynamic and diverse work environment.

Preferred:

  • Experience with gene editing screens and analysis of larger datasets.

  • Experience with CRISPR/Cas9-based gene editing.

  • Familiarity with cancer immunology and tumor microenvironment biology.

  • Experience with pluripotent stem cells.

Benefits:

  • Medical, Dental and Vision Insurance

  • Generous Paid Time Off options, including Vacation and Sick time, plus national holidays including year-end shut down

  • 401(k) match and annual company contribution

  • Company paid life insurance

  • Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions

  • Long Term Incentive Plan for eligible positions

  • Referral bonus program

#LI-LK

Category Research and Development

Astellas is committed to equality of opportunity in all aspects of employment. EOE including Disability/Protected Veterans

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