Astellas Pharma Scientist, Hematopoietic Cell Differentiation in Seattle, Washington

Universal Cells is now part of Astellas!

Developing innovative therapies is one of the most challenging, most essential and personally rewarding fields in science. This is the most exciting time to be a part of Astellas, a company with a uniquely collaborative and patient-focused culture.

There's something special about working at Astellas. It's reflected in our focus on the people we serve, the way we treat each other and the results we achieve together as a company.

Astellas is announcing a Scientist, Hematopoietic Cell Differentiation opportunity at their Universal Cells facility in Seattle, WA.

Purpose:

Universal Cells, a pre-eminent gene editing company, seeks an innovative, and highly-motivated Scientist, Hematopoietic Biology, to join our R&D team to differentiate and phenotype engineered human pluripotent stem cells for hematopoietic and immune applications.

In this role you should display strong investigative or technological orientation with independence of experimental design in both cases by performing complex analytical procedures and implementing new techniques. You may oversee lower level researchers in the execution, design and interpretation of experiments. You will contribute to the scientific literature, external conferences and/or scientific patents, where applicable. You will provide consultation to internal Research and Development groups. You may lead some aspect of a project in a small lab group. Has good presentation, written, and oral communication skills.

Essential Job Responsibilities:

  • Differentiate edited pluripotent stem cell lines into mature hematopoietic cell types.
  • Phenotype differentiated cells using assays including flow cytometry, imaging, gene expression, cytotoxicity, and antigen presentation analyses.
  • Develop and implement additional assays and methods to characterize cell function.
  • Collaborate closely with members of the gene editing team to exploit additional opportunities for cell engineering.
  • Collaborate with the PD team at Universal Cells to translate processes towards clinical applications.
  • Perform experiments with a careful attention to detail.
  • Accurately record procedures, data and results.
  • Interpret data, draw conclusions from experimental work, and present results in team meetings.

Qualifications:

Required

  • PhD with 0-3 years or MS with 5+ experience in academia or industry. Title will be commensurate with experience.
  • Extensive experience with Pluripotent Stem Cells/iPSCs.
  • Expertise with hematopoietic cell differentiation and regulation.
  • Cell lineage characterization using multi-color flow cytometry and imaging.
  • Experience with gene expression analysis.
  • Excellent written and oral communication skills
  • Diligence, and meticulous attention to detail in experimentation and record keeping.
  • Willingness to learn and enthusiasm to be part of the development of a cutting-edge therapy platform.

Preferred

  • Experience with cell isolation using magnetic beads and FACS.
  • Experience with live-cell imaging/automated video microscopy and analysis.
  • Experience with functional immune cell assays.
  • Experience with gene editing.
  • Proficient with R/RStudio.

Disclaimer

The statements above are intended to describe the general nature and level of work being performed by people assigned to this classification. They are not to be construed as an exhaustive list of all responsibilities, duties, and skills required of personnel so classified. All personnel may be required to perform duties outside of their normal responsibilities from time to time.

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Equal Opportunity Employer Minorities/Women/Protected Veterans/Disabled

Category Research and Development