Astellas Pharma Research Associate II, Cell Editing in Seattle, Washington
Universal Cells is focused on the development and commercialization of stem cell and regenerative medicine therapies. We conduct clinical-grade gene editing of stem cells and have a major effort in R&D. We design and produce stem cells that avoid rejection, and we engineer cells with improved therapeutic properties, all through our world-class gene editing platform.
Our goal is to provide cells for regenerative medicine applications that can treat all patients. Through internal R&D and our corporate partnerships, we are pursuing a diverse range of disease indications, including blindness, cancer, vascular insufficiency, and autoimmune diseases.
Universal Cells (UCI) is announcing a Research Associate II, Cell Editing opportunity at their facility in Seattle, WA .
The primary purpose of the Research Associate II for Cell Editing is to support the generation of clinical-grade, gene-edited Universal Donor Cells in a controlled manufacturing environment. This Research Associate II role will work as part of a team planning and executing all aspects of gene-editing and engineering of pluripotent stem cells. This position will be provided training to perform all required fundamental skills. Will assist with complex laboratory operations, keep appropriate documentation including lab notebooks, batch documentation and experimental summaries. Will be able to execute protocols with minimal guidance and will have the ability to summarize results independently. May assist in generating content and preparing controlled documents and data summaries. This position will acquire further versatility in routine procedures, technical knowledge, understanding of administrative operations, and general troubleshooting.
Universal Cells is a wholly-owned subsidiary of Astellas Pharma. Astellas is an R&D-driven global pharmaceutical company whose philosophy is to contribute to the improvement of people's health around the world through the provision of innovative and reliable pharmaceutical products.
Essential Job Responsibilities:
75% of the time will be spent in the laboratory environment on specified projects editing pluripotent stem cells using aseptic cell culture technique in a controlled manufacturing environment.
Assists with the designs, planning and execution of AAV-mediated gene-editing of pluripotent stem cells.
Demonstrates understanding and ability to record data using Good Documentation Practices.
Demonstrates ability to write and follow established SOPs.
Performs data collection and demonstrates understanding and ability to analyze, interpret, and summarize data for stem cell culture and gene-editing processes.
Communicates results in both oral and written formats in a timely manner and actively participates in team meetings (including cross-functional team meetings) and presentation preparations.
Prepares and reviews the work of others, including but not limited to, technical slide decks, reports, Standard Operating Procedures (SOPs) and production batch records.
Serves as a technical resource for preparation of regulatory filings.
Supports Process Development to transfer manufacturing processes.
Supports Process Development to identify and troubleshoot challenges in manufacturing operations.
Shows initiative in learning new protocols, relevant equipment, and related software.
Serves as a subject matter expert on experimental methods and production processes.
Ensures smooth day-to-day operations of the manufacturing lab.
Performs other duties as assigned or special projects as needed.
An MS with 0-2 years or a BS with 3+ years of highly relevant laboratory experience.
Strong organizational, time management and the ability to maintain accurate and up-to-date records.
Ability to troubleshoot and think critically, with scientific attention to detail.
Ability to work effectively both independently and with other team members.
Excellent communication and interpersonal skills.
Excellent work planning, organization, and record keeping.
Strong work ethic with a passion for working in a fast-paced, dynamic and diverse work environment.
Flexibility to work shifted schedule with at least one weekend day.
Experience working in a GMP environment is highly preferred.
Experience with pluripotent stem cell culturing.
Experience with gene editing of pluripotent stem cells.
Category Research and Development
Astellas is committed to equality of opportunity in all aspects of employment. EOE including Disability/Protected Veterans