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Astellas Pharma Research Associate II, Cell Biology in Marlborough, Massachusetts

The Astellas Institute of Regenerative Medicine (AIRM) is a wholly-owned subsidiary of Astellas Pharma and focused on the development and commercialization of stem cell and regenerative medicine therapies. Astellas is an R&D-driven global pharmaceutical company whose philosophy is to contribute to the improvement of people's heath around the world through the provision of innovative and reliable pharmaceutical products.

Developing innovative therapies is one of the most challenging, most essential and personally rewarding fields in science. This is the most exciting time to be a part of Astellas, a company with a uniquely collaborative and patient-focused culture. There's something special about working at Astellas. It's reflected in our focus on the people we serve, the way we treat each other and the results we achieve together as a company.

AIRM has a world-class R&D team, and is pursuing a diverse range of disease indications, ranging from macular degeneration (currently in clinical trials) and other ocular indications to vascular and autoimmune disease. AIRM's intellectual property portfolio includes pluripotent stem cell platforms -- both embryonic and induced pluripotent stem cells as well as other cell based therapy research programs. AIRM is headquartered in Marlborough, Massachusetts.

Purpose:

We are seeking a highly motivated and energetic Research Associate 2 to join the Ocular Research team. This person will assist with process development projects in collaboration with other members of our group, maintain accurate records and perform routine laboratory duties such as restocking supplies, ordering and equipment maintenance. On-the-job training for specific operations will be provided but as a high level of scientific curiosity is a must.

Essential Job Responsibilities:

  • Responsible for culturing, maintenance, characterization and differentiation of pluripotent stem cell lines
  • Perform RNA and Protein expression analysis using qPCR, ICC/IHC, ELISA, FACS, and Western Blotting
  • Perform cloning, plasmid, and virus transfection
  • Make detailed observations, analyze data, interpret results, data visualization, and maintain records
  • Participate in team discussions and contribute to experimental design
  • Ensure proper maintenance of laboratory reagents and equipment
  • Establish strong collaboration and communication with a multidisciplinary cross-cultural team

Qualifications:

Required

  • BS/MS or equivalent with 3+ years of relevant experience; MS with 0-2 years of laboratory experience
  • Expertise in stem cell research including cell culture, stem cell analysis, and differentiation
  • Solid work experience in one or more of the following techniques: immunocytochemistry/immunohistochemistry, western blotting, and flow cytometry
  • Working knowledge of molecular biology techniques such as DNA/RNA prep, qPCR, and ELISA
  • Well organized, detail-oriented, adhere to SOPs, data collection, data management, and record keeping
  • Excellent oral and written communication, and interpersonal skills
  • Ability to work both independently and in a team setting
  • Adept learner with an ability to identify and troubleshoot complex problems

Preferred

  • Experience in the ocular field is preferred
  • Experience with bioinformatics analysis of transcriptomic data is preferred
  • Experience in state-of-the-art molecular biology techniques such as single cell analysis and CRISPR is preferred

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Equal Opportunity Employer Minorities/Women/Protected Veterans/Disabled

Category Research and Development

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