Astellas Pharma Associate Director, Immunobiology (Mitobridge) in Cambridge, Massachusetts
Developing innovative therapies is one of the most challenging, most essential and personally rewarding fields in science. This is the most exciting time to be a part of Astellas, a company with a uniquely collaborative and patient-focused culture.
There's something special about working at Astellas. It's reflected in our focus on the people we serve, the way we treat each other and the results we achieve together as a company.
Astellas is announcing an Associate Director, Immunobiology opportunity at their Mitobridge site in Cambridge, MA.
At Mitobridge, we are passionate about developing novel therapeutics that improve mitochondrial function to treat devastating human diseases. Mitochondrial dysfunction is increasingly linked to disease pathologies and we believe that 'normalizing' mitochondrial function can ameliorate or reverse disease states.
The role of the Associate Director is to build and oversee preclinical drug development programs related to immunobiology/immunometabolism. The candidate will assume responsibility for the design and execution of all non-clinical work up to and including the IND-enabling studies and will be a major contributor to clinical strategy leading to proof of concept in humans.
The successful candidate will be an outstanding scientist with expertise in immunology and experience in overseeing the design, execution and interpretation of non-clinical pharmacology and toxicology studies. Experience preparing successful IND submissions in a pathophysiology/biology driven approach is essential. S/he will be expected to develop and maintain strong collaborations and relations with external experts in the non-clinical and clinical fields of immunology, immunometabolism, immune disorders and immuno-oncology. The candidate will also coordinate with other immunology experts within the Astellas global drug development team and seek synergies with the mitochondria primary focus.
Essential Job Responsibilities:
Lead and/or participate multiple immuno-biology focused projects within discovery, provide scientific expertise, guidance and strategy to successfully bringing programs to IND submission.
Propose, plan and manage and execute studies to characterize the company's drug candidates and their mechanism of action to move programs from discovery to clinical development in immune related indications.
Plan and implement translational research including investigation of pharmacodynamics markers of target engagement, markers predictive of or correlating with clinical efficacy and disease biology
Responsible for preparation of study reports, regulatory filings and project presentations
Manage a portfolio of targets related to immunobiology, oversee strategic execution of discovery research and preclinical activities to enable robust, timely and compliant IND submissions with clear development paths
Provide expert level guidance in designing and implementing cell biology, in vivo pharmacology and biomarker related studies
Partner with additional immunology experts to integrate mitochondria / metabolism focused programs with other immune related programs in the pipeline
Interface with external partners, clinical and academic collaborators, and CROs
Provide high-level updates and advice to senior management, including evaluation of data and their potential impact on drug programs and clinical/regulatory strategy
Lead (directly & indirectly through projects) the immuno-biology aspects of ongoing and future projects. Provide development opportunities and mentoring to direct reports.
Keep abreast of emerging developments regarding research and development in the fields of immune related disorders, emerging new biology and new modalities that could facilitate identification of new targets or development of new therapeutics
Ph.D. with 8 + years, MS with 10 + years or BS with 15 + years of highly relevant immunobiology experience in a biopharmaceutical setting
Direct hands-on experience co-leading drug discovery projects from target validation to IND-enabling studies in the immunology field
Demonstrated creativity and novel approaches to solving scientific problems
Knowledge of preclinical and clinical biomarker discovery and development
Good understanding of preclinical PK/PD/efficacy relationships and their translation to the clinic
Strong leadership, interpersonal and communication skills with an enthusiasm for participating in a fast-paced environment characterized by rigorous science and innovative thinking
Demonstrated application of expertise to drug discovery in the immunology therapeutic area
Significant experience as a team member and/or leading multi-disciplinary teams focused on small molecule drug discovery
Experience with engaging and managing external efforts with contract research organizations and academic collaborators
At home in a results-driven, highly accountable environment where you can make a clear impact
A team player and mentor, who listens effectively and invites response and discussion. A collaborator who communicates in an open, clear, complete, timely and consistent manner
Ph.D. with 10+ years highly relevant immunobiology experience in a biopharmaceutical setting
Experience in immunobiology, mitochondrial biology, small molecule pharmacology.
Broad disease related experience with firsthand knowledge in either immuno-oncology and/or autoimmune diseases
Experience working within large pharma organizations and/or biotech/start up environment
Deep understanding and experience of immunology experimental models from rodents to non-human primates and human disease samples
Category Research and Development
Astellas is committed to equality of opportunity in all aspects of employment. EOE including Disability/Protected Veterans